We've been using this site for over 5 years now and although we regularly check the Web for comparisons (you never know!) they still have the best deals going and it saves hours of Web-trawling. you also get an up-to-date live pricing system so sometimes your selected flight is cheaper than the original quote. Very nice LOL. It's helpful to know when it's the other way round too!
skyscanner We still use them to fly back to UK when we need to. Also, best car-hire deals are currently with carjet.com
Hope this helps?